Highlighted Publication

Yang, L.#, Chang, S.#, Lu, Q., Zhang, Y., Wu, Z., Sun, X., Cao, Q., Qian, Y., Jia, T., Xu, B., Duan, Q., Li, Y., Zhang, K., Gunter, S., Lu, L., Liu, D.,*, Wang, J.,*, Wang, Y.*, Lu, L. (2017). A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder. Mol Psychiatry. doi:10.1038/mp.2017.74 (IF: 13.204
该工作与北医六院合作发现了注意缺陷多动障碍儿童中与抑制控制相关的基因MICALL2。
Li, Y.#, Zhang, K.#, Chen, H., Sun, F., Xu, J., …Wang, J.* & Zhang, F.* (2013). A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren’s syndrome at 7q11.23. Nature Genetics 45(11) 1361-1365. doi:10.1038/ng.2779 (IF: 27.959
该工作与协和医院合作利用GWAS技术发现了干燥综合症相关的遗传基因。
Chang, S.#, Gao, L.#, Li, Z.#, Zhang, W.#, Du, Y., & Wang, J.* (2013). BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder. Biol Psychiatry. doi: 10.1016/j.biopsych.2013.04.016 (IF: 11.212
该工作构建了整合精神分裂症和重度抑郁症遗传位点的双相情感障碍遗传学数据库。
Zhang, L.#, Chang, S.#, Li, Z., Zhang, K., Du, Y., Ott, J., & Wang, J.* (2012). ADHDgene: a genetic database for attention deficit hyperactivity disorder. Nucleic Acids Res, 40(Database issue), D1003-1009. doi: 10.1093/nar/gkr992 (IF: 10.162
该工作构建了国际上第一个注意缺陷多动障碍遗传学数据库。
Zhang, K.#, Cui, S.#, Chang, S., Zhang, L., & Wang, J.* (2010). i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acids Res, 38(Web Server issue), W90-95. doi: 10.1093/nar/gkq324
Zhang, K.#, Chang, S., Cui, S., Guo, L., Zhang, L., & Wang, J.* (2011). ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res, 39(Web Server issue), W437-443. doi: 10.1093/nar/gkr391
(IF: 10.162)
该工作构建了系列GWAS数据通路分析网络平台。
Wang, J.#, Qu, S., Wang, W., Guo, L., Zhang, K., Chang, S.*, & Wang, J.* (2016). A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex. J Psychiatr Res, 82, 23-29. doi: 10.1016/j.jpsychires.2016.07.016 (IF: 4.465
该工作对双相情感障碍前额叶脑区基因表达谱进行整合分析,鉴定了多个差异表达基因,并对基因进行了功能网络分析。

Publications List

(underline is group member, # first author, * corresponding author)
1. Qu, S., Du, Y., Chang, S., Guo, L., Fang K., Li, Y., Zhang, F., Zhang, K.* & Wang, J.* (2017) Common variants near IKZF1 are associated with primary Sjogren's syndrome in Han Chinese. PLoS One (in press)
2. Yang, L.#, Chang, S.#, Lu, Q., Zhang, Y., Wu, Z., Sun, X., Cao, Q., Qian, Y., Jia, T., Xu, B., Duan, Q., Li, Y., Zhang, K., Gunter, S., Lu, L., Liu, D., * Wang, J., * and Wang, Y.* Lu, L. (2017). A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder. Mol Psychiatry. doi:10.1038/mp.2017.74
3. Piao, W.#, Guo, J.#, Bao, Y., Wang, F., Zhang, T., Huo, J.* & Zhang, K.* (2016). Analysis of polymorphisms of genes associated with folate-mediated one-carbon metabolism and neural tube defects in Chinese Han population. Birth Defects Research Part A: Clinical and Molecular Teratology, 106(4) 232-239.
4. Wang, J., Qu, S., Wang, W., Guo, L., Zhang, K., Chang, S.*, & Wang, J.* (2016). A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex. J Psychiatr Res, 82, 23-29. doi: 10.1016/j.jpsychires.2016.07.016
5. Fang, K., Zhang, K., & Wang, J.* (2015). Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese. Sci Rep, 5, 18855. doi: 10.1038/srep18855
6. Chang, S.#, Wang, J.#, Zhang, K., & Wang, J.* (2015). Pathway-based analysis for genome-wide association study data of bipolar disorder provides new insights for genetic study. Protein & Cell. doi: 10.1007/s13238-015-0201-1
7. Chang, S.#, Fang, K.#, Zhang, K., & Wang, J*. (2015). Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals. PLoS One, 10(7), e0133404. doi: 10.1371/journal.pone.0133404
8. Zong, L., Guan, J., Ealy, M., Zhang, Q., Wang, D., Wang, H., …Chang, S., …Wang, J,, …et al. (2015) Mutations in apoptosis-inducing factor cause X-linked recessive auditory neuropathy spectrum disorder. Journal of medical genetics.
9. Zhang, K.L.#, Chang, S.H.#, Guo, L.Y., Wang, J.* (2014) I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study. Protein & Cell. DOI 10.1007/s13238-014-0114-4
10. Guo, L.Y., Du, Y., Chang, S.H., Zhang, W.N., Wang, J.* (2014). Applying differentially expressed genes from rodent models of chronic stress to researches of stress-related disease: an online database. Psychosomatic Medicine.
11. Li, Z.#, Chang, S.#, Zhang, L.#, Gao, L., & Wang, J.* (2014). Molecular genetic studies of ADHD and its candidate genes: a review. Psychiatry Research, doi: 10.1016/j.psychres.2014.05.005
12. Gao, L., Li, Z., Chang, S., & Wang, J.* (2014). Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis. PLoS One, 9(3), e90407. doi: 10.1371/journal.pone.0090407
13. Guo, L.#, Du, Y.#, Chang, S., Zhang, K., & Wang, J.* (2014). rSNPBase: a database for curated regulatory SNPs. Nucleic Acids Res, 42 (D1): D1033-D1039. doi: 10.1093/nar/gkt1167
14. Li, Y. Z.#, Zhang, K. L.#, Chen, H.#, Sun, F., Xu, J. J., …Wang, J.* & Zhang, F., C.* (2013). A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren’s syndrome at 7q11.23. Nature Genetics 45(11), 1361-1365. doi:10.1038/ng.2779
15. Zhang, W. N., Chang, S. H., Guo, L. Y., Zhang, K. L., & Wang, J.* (2013). The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies. J Affect Disord. doi: 10.1016/j.jad.2013.06.039
16. Chang, S. H.#, Gao, L.#, Li, Z.#, Zhang, W. N.#, Du, Y., & Wang, J.* (2013). BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder. Biol Psychiatry. doi: 10.1016/j.biopsych.2013.04.016
17. Guo, L.#, Zhang, W.#, Chang, S.#, Zhang, L., Ott, J., & Wang, J.* (2012). MK4MDD: a multi-level knowledge base and analysis platform for major depressive disorder. PLoS One, 7(10), e46335. doi: 10.1371/journal.pone.0046335
18. Chang, S., Zhang, W., Gao, L., & Wang, J.* (2012). Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources. Protein & Cell, 3(7), 526-534. doi: 10.1007/s13238-012-2931-7
19. Zhang, L.#, Chang, S.#, Li, Z., Zhang, K., Du, Y., Ott, J., & Wang, J.* (2012). ADHDgene: a genetic database for attention deficit hyperactivity disorder. Nucleic Acids Res, 40(Database issue), D1003-1009. doi: 10.1093/nar/gkr992
20. Zhang, K., Chang, S., Cui, S., Guo, L., Zhang, L., & Wang, J.* (2011). ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res, 39(Web Server issue), W437-443. doi: 10.1093/nar/gkr391
21. Zhang, K. L., Zhang, L. Y., Zhang, W. N., & Wang, J.* (2011). Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study. Chinese Science Bulletin, 56(32), 3398-3402. doi: DOI 10.1007/s11434-011-4742-2
22. Yang, L.#, Zhang, K.#, Dai, W., He, X., Zhao, Q., Wang, J.* & Sun, Z. S.* (2011). Systematic evaluation of genome-wide methylated DNA enrichment using a CpG island array. BMC Genomics, 12, 10. doi: 10.1186/1471-2164-12-10 [Q1, IF: 3.986, 5-year IF: 4.360]
23. Fang, K., Zhao, H., Sun, C., Lam, C. M., Chang, S., Zhang, K., . . . Wang, J.* (2011). Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. BMC Syst Biol, 5, 83. doi: 10.1186/1752-0509-5-83
24. Zhang, J., Mamlouk, A. M., Martinetz, T., Chang, S., Wang, J., & Hilgenfeld, R.* (2011). PhyloMap: an algorithm for visualizing relationships of large sequence data sets and its application to the influenza A virus genome. BMC Bioinformatics, 12, 248. doi: 10.1186/1471-2105-12-248
25. Yan, H. Q., Chang, S. H., Tian, Z. X., Zhang, L., Sun, Y. C., Li, Y., . . . Wang, J., & Wang, Y. P.* (2011). Novel AroA from Pseudomonas putida confers tobacco plant with high tolerance to glyphosate. PLoS One, 6(5), e19732. doi: 10.1371/journal.pone.0019732
26. Zhang, L. Y., Chang, S. H., & Wang, J.* (2011). Synthetic biology: From the first synthetic cell to see its current situation and future development. Chinese Science Bulletin, 56(3), 229-237. doi: DOI 10.1007/s11434-010-4304-z
27. Zhang, L. Y., Chang, S. H., & Wang, J.* (2010). How to make a minimal genome for synthetic minimal cell. Protein & Cell, 1(5), 427-434. doi: DOI 10.1007/s13238-010-0064-4
28. Zhang, K.#, Cui, S.#, Chang, S., Zhang, L., & Wang, J.* (2010). i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acids Res, 38(Web Server issue), W90-95. doi: 10.1093/nar/gkq324
29. Zhu, X.#, Chang, S.#, Fang, K., Cui, S., Liu, J., Wu, Z., . . . Wang, J.* (2009). MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium. BMC Microbiol, 9, 40. doi: 10.1186/1471-2180-9-40
30. Fellay J #, Ge D #, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A, De Luca A, Easterbrook P, Günthard HF, Mallal S, Mussini C, Dalmau J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ, Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE, Beckmann JS, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Feng S, Telenti A *, Goldstein DB *; NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI). (2009) Common genetic variation and the control of HIV-1 in humans. PLoS Genetics 5: e1000791.
31. He, X.#, Chang, S.#, Zhang, J.#, Zhao, Q.#, Xiang, H., Kusonmano, K., . . . Wang, J.* (2008). MethyCancer: the database of human DNA methylation and cancer. Nucleic Acids Res, 36(Database issue), D836-841. doi: 10.1093/nar/gkm730
32. Ge D *, Zhang K, Need AC, Martin O, Fellay J, Telenti A and Goldstein DB *. (2008) WGAViewer: A software tool for genomic annotation of whole genome association studies. Genome Research 18(4) 640-3.
33. Ortiz M, Kaessmann H, Zhang K, Bashirova A, Carrington M, Quintana-Murci L, Telenti A *. (2008) The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates. Genes & Immunity 9(6) 483-92.
34. Zhang K-L, Mangeat B, Ortiz M, Zoete V, Trono D, Telenti A *, & Michielin O *. (2007) Model structure of human APOBEC3G. PLoS ONE 2(4) e378.
35. Rotger M #, Saumoy M #, Zhang K, Flepp M, Sahli R, Decosterd L, Telenti A * and the Swiss HIV Cohort Study. (2007) Partial deletion of CYP2B6 owing to unequal crossover with CYP2B7. Pharmacogenetics and Genomics 17(10) 885-90.
36. Chang, S#., Zhang, J.#, Liao, X.#, Zhu, X., Wang, D., Zhu, J., . . . Wang, J.* (2007). Influenza Virus Database (IVDB): an integrated information resource and analysis platform for influenza virus research. Nucleic Acids Res, 35(Database issue), D376-380. doi: 10.1093/nar/gkl779
37. Fellay J, Shianna KV, Ge D, Colombo S, Ledergerber B, Weale M, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, Luca AD, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A *, and Goldstein DB *. (2007) A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1. Science (ScienceXpress, 19 July 2007) 317(5840) 944-7.
38. Zhang Z, Sun S, Zhu X, Chang S, Liu X, Yu C et al. A novel scoring schema for peptide identification by searching protein sequence databases using tandem mass spectrometry data. BMC Bioinformatics 2006; 7: 222.
39. Zhang K, Luo JC, Liu CQ *. (2005) Exploring consensus mRNA secondary (folding) structure units by stochastic sampling and folding simulation. Journal of Molecular Structure: THEOCHEM 715(1-3) 15-20.
40. Zhang K-L, Zhang J *, Luo JC. (2005) Potential Transcriptional Synergy between Upstream Regions and Introns of Yeast Genes. Progress in Biochemistry and Biophysics 32(1) 46-52.
41. Zhang K-L, Zhang J, Luo J-C. (2005) Possible Short- and Long-Range Transcriptional Synergistic Regulation between Upstream Regions and Introns in Yeast Genes. Acta Biophysica Sinica 21(4) 277. (in Chinese)
42. Zhou W, Chen X-F, Zhang K-L, Liu C-Q *. (2005) The identification and quantification of highly stable ‘common hairpin’ in the dynamic process of co-transcriptional mRNA folding. Journal of Molecular Structure: THEOCHEM 722(1-3) 41-50.
43. Zhong L, Zhang K, Huang X, Ni P, Han Y, Wang K, Wang J, Li S. (2003) A statistical approach designed for finding mathematically defined repeats in shotgun data and determining the length distribution of clone-inserts. Genomics, Proteomics & Bioinformatics 1(1) 43-51.
44. Yu J #, Hu S #, Wang J #, Wong GK #, Li S, Liu B, Deng Y, Dai L, Zhou Y, Zhang X, Cao M, Liu J, Sun J, Tang J, Chen Y, Huang X, Lin W, Ye C, Tong W, Cong L, Geng J, Han Y, Li L, Li W, Hu G, Huang X, Li W, Li J, Liu Z, Li L, Liu J, Qi Q, Liu J, Li L, Li T, Wang X, Lu H, Wu T, Zhu M, Ni P, Han H, Dong W, Ren X, Feng X, Cui P, Li X, Wang H, Xu X, Zhai W, Xu Z, Zhang J, He S, Zhang J, Xu J, Zhang K, Zheng X, Dong J, Zeng W, Tao L, Ye J, Tan J, Ren X, Chen X, He J, Liu D, Tian W, Tian C, Xia H, Bao Q, Li G, Gao H, Cao T, Wang J, Zhao W, Li P, Chen W, Wang X, Zhang Y, Hu J, Wang J, Liu S, Yang J, Zhang G, Xiong Y, Li Z, Mao L, Zhou C, Zhu Z, Chen R, Hao B, Zheng W, Chen S, Guo W, Li G, Liu S, Tao M, Wang J, Zhu L *, Yuan L *, Yang H *. (2002) A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science 296(5565) 79-92.
45. Wang J *, Wong GK *, Ni P, Han Y, Huang X, Zhang J, Ye C, Zhang Y, Hu J, Zhang K, Xu X, Cong L, Lu H, Ren X, Ren X, He J, Tao L, Passey DA, Wang J, Yang H, Yu J, Li S. (2002) RePS: a sequence assembler that masks exact repeats identified from the shotgun data. Genome Research 12(5) 824-31.